To explore the universe of GPCR heteromers, we capitalized on our Ad-BiFC heteromer finder technology. Using adenovirus-based BiFC (Bimolecular Fluorescence Complementation) vector, we established a library of Ad-BiFC heteromer finders tagging more than 160 GPCRs. This technology can be used as HTS (High Throughput Screening) / HCS (High Contents Screening) platform for the research on GPCR heteromerization.