Platform Technology
Publication
2026
Sukhtankar, D.D., Cardarelli, P.M., Jalilizeinali, B. et al. (2026).
Burixafor, a CXCR4 inhibitor with a differentiated kinetics profile: results of a phase 2 study for rapid cell mobilization in multiple myeloma and lymphoma patients undergoing transplant.
Ann Hematol 105, 86
2026
Jang, S., Jeong, J.-Y., and Huh, W.-K. (2026).
Activation of the pituitary adenylate cyclase-activating polypeptide type I receptor promotes neuroblastoma proliferation and migration through distinct G protein pathways.
Cell Commun Signal 24, 105
2025
Lee, J.-W., Lee, D.-Y., Baek, S., Jeong, J.-Y., and Huh, W.-K. (2025).
Sensitive detection of pertussis toxin in acellular pertussis vaccines using HRH1-mediated calcium signaling.
Vaccine, Volume 54, 2025, 127056
2025
Kim, H.-T., Jeong, J.-Y., and Huh, W.-K. (2025).
Regulation of CXCR4 function by S1P1 through heteromerization.
Cell Commun Signal 23, 111
2024
Caculitan, N., Kim, G., Woolfrey, A., Akard, L.P., Jeong, A.-R., Khouri, J., Shah, G.L., Cardarelli, P.M. et al. (2024).
An open-label, multi-center phase 2 study to assess the safety and efficacy of Burixafor (GPC-100) and propranolol with G-CSF for the mobilization of stem cells in patients with Multiple Myeloma undergoing autologous stem cell transplant.
Blood (2024) 144 (Supplement 1): 4858.
2024
Sukhtankar, D.D., Cayton, T., Chin, A., Ramos, C., et al. (2024).
Strategy to Improve Functional T-Cell Yield in Peripheral Blood by Co-Inhibition of Beta-2 Adrenergic and CXCR4 Signaling Pathways.
Blood (2024) 144 (Supplement 1): 4852.
2024
Tang, Y., Braun, A., von Behren, Z., Wu, J., Haley, C., Zhang, C., et al. (2024).
Combined CXCR-4 Inhibition with Novel Agent GPC-100 (Burixafor) and Beta 2 Adrenergic Receptor Blockade Enhances Cytarabine Response for Acute Myeloid Leukemia Blasts on Stroma.
Blood (2024) 144 (Supplement 1): 2758.
2024
Loera, B., Zhang, C., Cardarelli, P.M., Caculitan, N.G., et al. (2024).
Toward optimizing CXCR4 inhibition with beta adrenergic blockade to enhance chemotherapy response in AML.
Cancer Res (2024) 84 (6_Supplement): 732.
2024
Liang, J., Seghiri, M., Singh, P.K., Seo, H.G., Lee, J.Y., et al. (2024).
The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 121 (14) e2304897121.
2023
Sukhtankar DD, Fung JJ, Kim M, Cayton T, Chiou V, Caculitan NG, et al. (2023).
GPC-100, a novel CXCR4 antagonist, improves in vivo hematopoietic cell mobilization when combined with propranolol.
PLOS ONE 18(10): e0287863.
2023
LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration.
Cell Commun. Signal., 21(257)
2023
Pharmacokinetics and Pharmacodynamics of Burixafor Hydrobromide (GPC-100), a Novel C-X-C Chemokine Receptor 4 Antagonist and Mobilizer of Hematopoietic Stem/Progenitor Cells, in Mice and Healthy Subjects.
Clin. Pharmacol. Drug Dev., 12(11),1114-1120.
2023
Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
Sci. Rep., 13(), 1894.
2020
Lim, G., Chang, Y., and Huh, W.-K. (2020).
Phosphoregulation of Rad51/Rad52 by CDK1 functions as a molecular switch for cell cycle-specific activation of homologous recombination.
Sci. Adv., 6(6), eaay2669.
2019
Genome-wide studies of Rho5-interacting proteins that are involved in oxidant-induced cell death in budding yeast.
G3(Bethesda), 9(3), 921-931.
2019
Global analysis of protein homomerization in Saccharomyces cerevisiae.
Genome Res., 29(1), 135-145.
2015
Bimolecular fluorescence complementation (BiFC) analysis: advances and recent applications for genome-wide interaction studies.
Mol. Biol., 427(11), 2039-2055.
2014
Monitoring G protein-coupled receptor activation using an adenovirus-based beta-arrestin bimolecular fluorescence complementation assay.
Anal. Biochem., 449(), 32-41.
2013
Genome-wide bimolecular fluorescence complementation analysis of SUMO interactome in yeast.
Genome Res., 23(4), 736-746.
2012
Choi, E.-W., Seen, D.-S., Song, Y. B., H.-S., Jung, N.-C., Huh, W.-K., Hahn, J.-S., Kim, K., Jeong, J.-Y., and Lee, T. G. (2012).
AdHTS: A high-throughput system for generating recombinant adenoviruses.
Biotechnol., 162(2-3), 246-252
2011
Pu, J., Ha, C. W., Zhang, S., Jung, J. P., Huh, W.-K., and Liu, P. (2011).
Interactomic study on interaction between lipid droplets and mitochondria.
Protein & Cell, 2(6), 487-496.
2010
Sung, M.-K., and Huh, W.-K. (2010).
In vivo quantification of protein-protein interactions in Saccharomyces cerevisiae using bimolecular fluorescence complementation assay.
J. Microbiol. Methods, 83(2), 194-201.
2007
Sung, M.-K., and Huh, W.-K. (2007).
Bimolecular fluorescence complementation analysis system for in vivo detection of protein-protein interaction in Saccharomyces cerevisiae.
Yeast, 24(), 767-775.