Product
CXCR4
- Gαi-protein coupled receptor that binds to CXCL12
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CXCR4 is overexpressed in more than 23 different cancer types
- Plays pivotal role in cancer progression by regulating tumor growth, metastasis, angiogenesis, and therapeutic resistance
- In patients, high expression of CXCR4 correlates with poor survival and lower levels of relapse free survival